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Renal function outcomes for multifocal renal neoplasms managed by radiofrequency ablation
Pushpender Gupta1, Brian C Allen, Michael Y Chen
1Department of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA, pugupta@wakehealth.edu.
Cardiovascular and Interventional Radiology
|January 31, 2013
Summary
Radiofrequency ablation (RFA) for multifocal renal neoplasms causes a mild decrease in kidney function. Renal function decline is more pronounced with larger tumors and in patients with pre-existing renal impairment.
Area of Science:
- Nephrology
- Oncology
- Interventional Radiology
Background:
- Multifocal renal neoplasms require effective treatment options.
- Radiofrequency ablation (RFA) is a minimally invasive technique used for tumor ablation.
- Evaluating the impact of RFA on renal function is crucial for patient management.
Purpose of the Study:
- To assess changes in renal function following radiofrequency ablation (RFA) for multifocal renal neoplasms.
- To identify factors influencing renal function decline after RFA.
Main Methods:
- Retrospective study of 57 patients undergoing computed tomography-guided RFA for 169 renal neoplasms.
- Estimated glomerular filtration rate (eGFR) was measured pre- and post-RFA.
- Complication rates were recorded.
Main Results:
- eGFR decreased by 4.4% per tumor treated and 6.7% per ablation session.
- Tumor size significantly impacted eGFR decline, with larger tumors (>3 cm) showing a 14.5% decrease.
- Patients with reduced baseline renal function experienced a greater eGFR decline.
Conclusions:
- Radiofrequency ablation for multifocal renal neoplasms leads to a mild decline in renal function.
- The extent of renal function impairment is related to tumor burden and baseline renal status.
