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Related Concept Videos

Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
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Cerebral Edema l: Introduction

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Cerebral Edema ll: Pathophysiology01:22

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Alterations in Muscle Tone ll01:12

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Related Experiment Video

Updated: May 14, 2026

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

Cerebral palsy--don't delay.

Sarah McIntyre1, Cathy Morgan, Karen Walker

  • 1Cerebral Palsy Alliance, Research Institute, New South Wales, Australia. smcintyre@cerebralpalsy.org.au

Developmental Disabilities Research Reviews
|January 31, 2013
PubMed
Summary
This summary is machine-generated.

Early detection of cerebral palsy (CP) is crucial. The general movements assessment in infants can predict CP risk, enabling earlier intervention for better outcomes.

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Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations
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Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy
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Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy

Published on: January 11, 2016

Related Experiment Videos

Last Updated: May 14, 2026

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations
05:04

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations

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Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy
08:26

Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy

Published on: January 11, 2016

Area of Science:

  • Neurology
  • Developmental Pediatrics
  • Physical Medicine and Rehabilitation

Background:

  • Cerebral palsy (CP) is a severe physical disability resulting from brain injury during development.
  • CP encompasses diverse motor disorders and associated impairments, with unclear etiological pathways for most cases.
  • Early differentiation between CP and other developmental delays is critical for appropriate management.

Purpose of the Study:

  • To advocate for a paradigm shift in diagnostic practices for cerebral palsy.
  • To emphasize the importance of early identification and intervention for infants at risk of CP.

Main Methods:

  • Utilizing the general movements assessment to evaluate spontaneous infant movements in the first four months of life.
  • Focusing on predictive tools for early identification of potential CP cases.

Main Results:

  • The general movements assessment is identified as the most promising predictive tool for CP.
  • Current diagnostic practices often lead to late identification and intervention.

Conclusions:

  • A proactive approach is recommended, shifting from late CP diagnosis to early intervention for at-risk infants.
  • Implementing early referral for intervention based on risk assessment can improve outcomes for children with CP.