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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Respiratory syncytial virus-associated hospitalizations in Louisiana
Jenna Iberg Johnson1, Raoult Ratard
1Louisiana Office of Public Health, Infectious Disease Epidemiology Section, USA.
Insights
Respiratory syncytial virus (RSV) causes significant hospitalizations in Louisiana children under one year old, primarily with bronchiolitis. Immunoprophylaxis is recommended during the November to March RSV season.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- Respiratory syncytial virus (RSV) is a leading cause of infant bronchiolitis and pneumonia globally.
- Understanding the epidemiology of RSV hospitalizations is crucial for public health interventions.
Purpose of the Study:
- To determine the burden of RSV hospitalizations in Louisiana from 1999 to 2010.
- To identify demographic and seasonal patterns of RSV infections in hospitalized children.
Main Methods:
- Utilized Louisiana Inpatient Hospital Discharge Data from 1999-2010.
- Identified cases using RSV diagnosis codes.
- Analyzed hospitalization rates, age distribution, and seasonality.
Main Results:
- 2,000-3,000 annual RSV hospitalizations occurred, with rates of 37.2-71.4 per 100,000 population.
- Bronchiolitis was the primary diagnosis (79%), predominantly affecting infants under one year (44% aged 0-3 months).
- The RSV season spanned November to March; most infections (96.1%) were community-acquired.
Conclusions:
- RSV poses a substantial burden on Louisiana's pediatric population, particularly young infants.
- Targeted immunoprophylaxis during the identified RSV season is recommended for high-risk infants.
- The findings support public health strategies for RSV prevention and management in this region.
Abstract:
Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis and pneumonia in children under one year of age worldwide. Records indicative of RSV cases were pulled from The Louisiana Inpatient Hospital Discharge Data based on RSV diagnosis codes to describe the burden of RSV infections in Louisiana from 1999 to 2010. Two thousand to three thousand hospitalized RSV cases occurred each year, with rates ranging from 37.2 to 71.4 hospitalizations per 100,000 population and the majority of cases (79%) being diagnosed with bronchiolitis. The vast majority of cases occurred in children under one year of age, and within that group, 44% of the cases occurred in children ages 0 to 3 months. The RSV season was found to occur from November to March, and immunoprophylaxis for high-risk infants should be given according to that season. Hospital-acquired versus community-acquired infections were also examined and most (96.1%) cases were community-acquired.
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