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Updated: May 14, 2026
Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
Published on: September 30, 2019
High throughput screening of biologically functional small molecules for modulating the expression of FGFR1OP2/wit3.0
William Cheng1, Ichiro Nishimura
1Weintraub Center for Reconstructive Biotechnology, University of California, Los Angeles School of Dentistry, USA. willcheng@ucla.edu
Abstract:
Oral wounds heal rapidly without scarring through yet unknown molecular mechanisms. A small cytoskeleton molecule identified in oral wound fibroblasts, FGFR1OP2/wit3.0, has been shown to accelerate wound closure in vitro and in vivo. The objective of this study was to elucidate the transcriptional mechanism of FGFR1OP2/ wit3.0 in fibroblasts using a high throughput drug-screening platform. This pilot study identified chemical compounds that could effectively modulate the FGFR1OP2/wit3.0 expression for future studies on effective wound management.
