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Related Experiment Videos

Case-control study of hyperpyrexia in children.

G Alpert1, E Hibbert, G R Fleisher

  • 1Division of Emergency Medicine, Children's Hospital, Harvard Medical School, Boston, MA 02115.

The Pediatric Infectious Disease Journal
|March 1, 1990
PubMed
Summary
This summary is machine-generated.

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Hyperpyrexia, or very high fever, in young children is not linked to higher rates of bacteremia or serious bacterial illness. These children require thorough evaluation but no special consideration beyond standard febrile child protocols.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Hyperpyrexia (temperature >= 41.1°C) is a concerning clinical sign in young children.
  • The association between hyperpyrexia and serious bacterial infections, including bacteremia, requires clarification.

Purpose of the Study:

  • To investigate the relationship between hyperpyrexia and the incidence of bacteremia and serious bacterial illness in pediatric patients.
  • To determine if hyperpyrexic children warrant different diagnostic or management approaches compared to those with lower-grade fevers.

Main Methods:

  • A retrospective case-control study was conducted.
  • Seventy-six hyperpyrexic children (>= 41.1°C) were compared to age- and condition-matched controls with lower fevers (39.1-41.0°C).
  • Diagnostic procedures, including blood cultures, urine cultures, chest X-rays, and white blood cell counts, were analyzed.

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Main Results:

  • Hyperpyrexic children underwent a significantly higher number of diagnostic procedures (P < 0.05).
  • However, the frequency of serious bacterial infections and bacteremia did not significantly differ between hyperpyrexic children and controls (P > 0.05).

Conclusions:

  • Hyperpyrexia in young children is not independently associated with an increased risk of bacteremia or serious bacterial illness.
  • While thorough evaluation is necessary, hyperpyrexic children do not require special consideration beyond that given to any febrile child.