Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of the COVID-19 pandemic on cardiovascular mortality and catherization activity during the lockdown in central Germany: an observational study.

Clinical research in cardiology : official journal of the German Cardiac Society·2020
Same author

Left untreated: the natural course of a thoracic aortic aneurysm.

Vascular·2013
Same author

Enterococcus septicemia due to a pacemaker lead infection.

Journal of cardiovascular medicine (Hagerstown, Md.)·2012
Same author

Hepatic portal venous gas after upper endoscopy in a patient with a gastrointestinal stromal tumor.

Journal of clinical ultrasound : JCU·2009
Same author

Exacerbation of Whipple disease by immunosuppressants.

Journal of clinical gastroenterology·2008
Same author

Clinical and immunologic characteristics in peripartum cardiomyopathy.

International journal of cardiology·2006

Related Experiment Video

Updated: May 14, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Swinging heart in acute pancreatitis.

Steffen Lamparter1, Henrike Sundermann

  • 1Department of Internal Medicine, Diakonie-Krankenhaus Wehrda, Marburg, Germany. Dr.S.Lamparter@dkh-wehrda.de

The American Journal of the Medical Sciences
|February 1, 2013
PubMed
Summary

This case report details a rare instance of cardiac tamponade due to pericardial effusion in acute pancreatitis. Successful endoscopic treatment of a pancreaticopericardial fistula offers a new therapeutic approach.

More Related Videos

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
06:28

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Related Experiment Videos

Last Updated: May 14, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
06:28

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Area of Science:

  • Gastroenterology
  • Cardiology
  • Endocrinology

Background:

  • Pericardial effusions and cardiac tamponade are rare complications of acute pancreatitis.
  • Established treatment protocols for this specific complication are lacking.

Purpose of the Study:

  • To report a case of acute pancreatitis complicated by cardiac tamponade secondary to a pancreaticopericardial fistula.
  • To highlight the successful endoscopic management of this rare condition.

Main Methods:

  • Diagnosis of acute pancreatitis and subsequent cardiac tamponade.
  • Initial management with pericardiocentesis and medical therapy.
  • Identification of a pancreaticopericardial fistula via endoscopic retrograde cholangiopancreatography (ERCP).
  • Endoscopic stent placement in the disrupted pancreatic duct.

Main Results:

  • A 57-year-old male with alcoholic acute pancreatitis developed recurrent pericardial effusions and cardiac tamponade.
  • Emergency pericardiocentesis provided temporary relief, but effusions recurred despite intrapericardial triamcinolone and octreotide.
  • ERCP confirmed a pancreaticopericardial fistula, which was successfully treated with pancreatic duct stent placement.
  • The patient experienced uneventful clinical recovery following the endoscopic intervention.

Conclusions:

  • This case represents the first successful endoscopic treatment of a pancreaticopericardial fistula causing cardiac tamponade in the context of acute pancreatitis.
  • Endoscopic management offers a viable and effective therapeutic option for this rare and life-threatening complication.