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Exercise training in solid organ transplant recipients: a systematic review and meta-analysis
Madeleine Didsbury1, Richard G McGee, Allison Tong
1Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.
Transplantation
|February 1, 2013
Summary
Supervised exercise training shows promise for improving cardiovascular health in solid organ transplant recipients, particularly cardiac transplant patients. However, more large-scale studies are needed to confirm these benefits and guide clinical practice.
Area of Science:
- Cardiovascular Health
- Transplantation Medicine
- Exercise Physiology
Background:
- Exercise training improves cardiovascular risk in non-transplanted individuals.
- Benefits and harms of exercise post-solid organ transplantation remain unclear.
Purpose of the Study:
- Assess health benefits and harms of supervised exercise training programs in solid organ recipients.
Main Methods:
- Systematic review of randomized controlled trials (RCTs).
- Searched MEDLINE, EMBASE, Transplant Library, and Cochrane Central Register up to June 2012.
Main Results:
- 15 RCTs with 643 patients (cardiac, kidney, lung, liver transplants) included.
- Cardiac transplant recipients showed improved maximal oxygen uptake with exercise.
- No significant improvements in lipids, blood pressure, glycemic control, or exercise capacity in other transplant groups.
Conclusions:
- Exercise training is a promising, yet unproven, intervention for solid organ transplant recipients.
- Current trials are small, short, and focus on surrogate outcomes.
- Large-scale RCTs are urgently needed to validate exercise programs for this population.
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