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Updated: Jan 26, 2026

Nondestructive Monitoring of Degradable Scaffold-Based Tissue-Engineered Blood Vessel Development Using Optical Coherence Tomography
Published on: October 3, 2018
Vascular tissue engineering of small-diameter blood vessels: reviewing the electrospinning approach
Enrico Ercolani1, Costantino Del Gaudio1, Alessandra Bianco1
1Department of Industrial Engineering, INSTM Research Unit Roma Tor Vergata, University of Rome 'Tor Vergata', Via del Politecnico 1, 00133, Rome, Italy.
Abstract:
Vascular tissue engineering is a relevant research field aimed at elaborating and proposing innovative solutions to overcome the drawbacks related to the use of conventional blood vessel substitutes, especially referring to small-diameter grafts. For this aim, electrospinning can be regarded as a valuable technique to produce novel scaffolds with several functional characteristics that can be usefully tailored for the application discussed here. The reproduction of the natural extracellular matrix obtained by processing bioresorbable polymers, either functionalized or not, is driving the biomedical research towards technical solutions that can lead to an actual therapeutic improvement. In this context, this paper reviews those studies focused on the selection of suitable biomaterials for vascular applications, their microstructure, the cell response to polymeric fibres and the strategies considered so far to modify and therefore enhance the performance of final electrospun scaffolds.
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