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Updated: May 14, 2026

Fabrication of the Composite Regenerative Peripheral Nerve Interface (C-RPNI) in the Adult Rat

Fabrication of the Composite Regenerative Peripheral Nerve Interface (C-RPNI) in the Adult Rat

Published on: February 25, 2020

A Bionic Neural Link for peripheral nerve repair.

Yong Ping Xu¹, Shih-Cheng Yen, Kian Ann Ng

¹Dept of Electrical and Computer Engineering, National University of Singapore, 4 Engineering Dr 3, Singapore. yongpingxu@nus.edu.sg

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|February 1, 2013

Summary

This summary is machine-generated.

This study introduces a Bionic Neural Link (BNL) to repair peripheral nerve injuries. The BNL chip, tested in animal models, shows full function for nerve regeneration.

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Published on: January 13, 2022

Area of Science:

Biomedical Engineering
Neuroscience
Materials Science

Background:

Peripheral nerve injuries with large gaps pose significant repair challenges.
Existing surgical methods are limited by nerve degeneration and muscle atrophy.

Purpose of the Study:

To propose and demonstrate a Bionic Neural Link (BNL) as a novel solution for peripheral nerve repair.
To present the design and in-vivo validation of a BNL prototype.

Main Methods:

Development of a monolithic single-channel BNL prototype using 0.35-µm CMOS technology.
Integration of 16 neural recording channels and one stimulation channel.
In-vivo animal experiments to test the BNL chip's functionality.

Main Results:

Successful development of a functional BNL prototype.
Demonstration of full chip function in in-vivo animal experiments.
Validation of the BNL concept for peripheral nerve repair.

Conclusions:

The Bionic Neural Link (BNL) presents a promising alternative for repairing peripheral nerve injuries.
The developed BNL chip technology shows potential for restoring nerve function.
Further research and development are warranted to translate this technology into clinical practice.