Automated measurement of pediatric cranial bone thickness and density from clinical computed tomography

Skull thickness and density measures of normal pediatric crania would inform multiple disciplines including neurosurgery, optical and magnetoelectrophysiological imaging, and biomechanical modeling of head trauma. We report on a new method for automated extraction of in vivo skull thickness and density measures of pediatric crania based on x-ray computed tomography scans (CT). Data were obtained from a clinical image repository for pediatric populations in whom no pathology was noted. Skull thickness and density measures were systematically obtained across the calvarium. We find a set of measures that correlated with physiological age that are likely to prove useful in multiple disciplines.