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Related Experiment Video

Updated: May 14, 2026

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
06:36

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

A CMOS-based on-chip neural interface device equipped with integrated LED array for optogenetics.

T Tokuda1, T Miyatani, Y Maezawa

  • 1Graduate School of Materials Science, NaraInstitute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, JAPAN. tokuda@ms.naist.jp

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|February 1, 2013
PubMed
Summary
This summary is machine-generated.

Researchers developed a new CMOS neural interface with an integrated micro light source array for optogenetics. This device enables simultaneous multi-site stimulation and on-chip optical imaging, advancing neural research capabilities.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Optogenetics requires precise light delivery for neural circuit control.
  • Existing optogenetic tools often lack integrated imaging and multi-site stimulation capabilities.
  • CMOS technology offers miniaturization and integration potential for neural interfaces.

Purpose of the Study:

  • To propose and demonstrate a novel CMOS-based neural interface device with an integrated micro light source array.
  • To enable advanced optogenetic applications through simultaneous multi-site stimulation and on-chip optical imaging.
  • To overcome limitations of existing LED array devices for optogenetics.

Main Methods:

  • Fabrication of a GaInN LED array on a sapphire substrate.
  • Assembly of the LED array with a multifunctional CMOS image sensor.
  • Demonstration of addressable LED operation and integrated optical imaging.

Main Results:

  • Successful integration of a GaInN LED array with a multifunctional CMOS image sensor.
  • Demonstrated addressable LED operation for precise light delivery.
  • Achieved simultaneous multi-site stimulation and on-chip optical imaging capabilities.

Conclusions:

  • The developed CMOS-based neural interface device is a significant advancement for optogenetics.
  • The device offers unique advantages, including simultaneous stimulation and imaging, not found in previous technologies.
  • This integrated system holds promise for future neuroscience research and therapeutic applications.