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Updated: May 14, 2026
05:48
Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
Inflammatory bowel disease and systemic AA amyloidosis
Prayman T Sattianayagam1, Julian D Gillmore, Jennifer H Pinney
1Department of Medicine, Centre for Amyloidosis and Acute Phase Proteins, National Amyloidosis Centre, University College London, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK.
Digestive Diseases and Sciences
|February 2, 2013
Summary
Systemic AA amyloidosis, a complication of inflammatory bowel disease (IBD), can cause kidney failure. Controlling IBD inflammation may resolve renal dysfunction, and kidney transplants offer excellent patient and graft survival.
Area of Science:
- Nephrology
- Gastroenterology
- Immunology
Background:
- Systemic AA amyloidosis is a known complication of inflammatory bowel disease (IBD).
- AA amyloidosis can lead to end-stage renal failure and mortality.
- The natural history of AA amyloidosis in IBD patients is not well understood.
Purpose of the Study:
- To evaluate the clinical phenotype, disease progression, and outcomes of patients with IBD and AA amyloidosis.
- To understand the impact of inflammation control on renal dysfunction in these patients.
- To assess patient and graft survival following renal transplantation.
Main Methods:
- Prospective follow-up of 26 IBD patients with AA amyloidosis at a single center (1989-2010).
- Evaluation of clinical presentation, disease progression, and renal outcomes.
- Kaplan-Meier analysis for time to end-stage renal disease and graft survival.
Main Results:
- Twenty-two patients had Crohn's disease, four had ulcerative colitis; fistulae/abscesses occurred in 10 Crohn's patients.
- All patients developed proteinuric renal dysfunction; it resolved in 5 with controlled inflammation but progressed in others.
- 15 patients reached end-stage renal disease; 6 underwent transplantation with excellent graft survival, though one graft failed due to amyloid recurrence.
Conclusions:
- AA amyloidosis is a serious complication of Crohn's disease and ulcerative colitis, causing proteinuric renal dysfunction.
- Renal dysfunction may resolve with effective suppression of inflammatory bowel disease activity.
- Renal transplantation provides excellent patient and graft survival in this population.
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