Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Progressive microcirculatory changes caused by hypercholesterolemia in rats.

D A Schuschke¹, J T Saari, D M Ackermann

¹Department of Physiology, University of Louisville School of Medicine, Kentucky 40292.

The American Journal of Physiology

|May 1, 1990

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Emotional Intelligence as a Component of Surgical Coaching: A Scoping Review.

Journal of surgical education·2024

Same author

Counted cycles method to measure the block inception time of kiloHertz frequency mammalian motor nerve block.

Journal of neuroscience methods·2019

Same author

Reduction of the onset response in kilohertz frequency alternating current nerve block with amplitude ramps from non-zero amplitudes.

Journal of neuroengineering and rehabilitation·2019

Same author

Early and advanced glycation end-products are increased in dietary copper deficiency.

The Journal of nutritional biochemistry·2004

Same author

Percutaneous excision of a facet joint cyst under CT guidance.

Cardiovascular and interventional radiology·2002

Same author

Isolated ventricular myocytes from copper-deficient rat hearts exhibit enhanced contractile function.

American journal of physiology. Heart and circulatory physiology·2001

Same journal

Blood coagulation in fish.

The American journal of physiology·2011

Same journal

Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

The American journal of physiology·2010

Same journal

The inactivation of placental toxin by human serum.

The American journal of physiology·2010

Same journal

Adrenal function following ovariectomy in the rat.

The American journal of physiology·2010

Same journal

Capillary permeability; perfusion of frog and guinea pig hind limbs.

The American journal of physiology·2010

Same journal

Evaluation of protective measures against sunburn.

The American journal of physiology·2010

See all related articles

High cholesterol in rats progressively impairs microcirculation, reducing vasoconstrictor responses and inflammatory leakage. These changes occur before any signs of atherosclerosis, suggesting early receptor desensitization.

Area of Science:

Cardiovascular Biology
Microcirculation Research
Atherosclerosis Pathogenesis

Background:

Hypercholesterolemia is a major risk factor for cardiovascular diseases.
Early microcirculatory alterations may precede atherosclerotic lesion development.

Purpose of the Study:

To investigate the progressive microcirculatory changes induced by hypercholesterolemia in a rat model.
To determine if these changes occur before the development of atherosclerosis.

Main Methods:

Intravital microscopy was used to study the cremaster muscle microcirculation in rats.
Rats were fed a high-cholesterol diet for 1, 3, or 5 weeks.
Vascular responses to norepinephrine and macromolecular leakage induced by histamine were assessed.

Related Experiment Videos

Main Results:

Hypercholesterolemia significantly reduced vasoconstrictor responses to norepinephrine after 3 weeks.
Macromolecular leakage was reduced after 5 weeks of the high-cholesterol diet.
Platelet thrombi formation showed a slight increase, but no atheromatous pathology was observed after 5 weeks.

Conclusions:

Elevated serum cholesterol induces progressive microcirculatory dysfunction, including receptor desensitization and reduced inflammatory response.
These functional changes occur before the histological evidence of atherosclerosis.
Findings suggest early microvascular impairment as a key event in hypercholesterolemia.