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Updated: May 14, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
[Anticoagulation and atrial fibrillation].
1Catharina Ziekenhuis Eindhoven, Eindhoven, The Netherland.
Atrial fibrillation (AF) increases stroke risk, especially in the elderly. This review covers anticoagulation risks for traditional and new drugs, addressing undertreatment concerns.
Area of Science:
- Cardiology
- Pharmacology
Context:
- Atrial fibrillation (AF) is the most common heart arrhythmia.
- AF incidence and stroke risk rise with age.
- Anticoagulation is crucial for AF stroke prevention.
Purpose:
- To review bleeding risks associated with anticoagulants in AF patients.
- To compare risks of traditional vitamin K antagonists and newer direct oral anticoagulants.
Summary:
- Elderly patients at high stroke risk are often undertreated due to perceived bleeding risks.
- This article details risks of vitamin K antagonists (VKAs).
- It also describes risks of direct thrombin inhibitors and factor Xa inhibitors.
Impact:
- Aims to inform treatment decisions for AF patients, particularly the elderly.
- Highlights the need to balance stroke prevention with bleeding risk management.
- Facilitates better understanding of anticoagulant safety profiles.
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