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Related Experiment Video

Updated: May 14, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Bladder cancer: a simple model becomes complex.

Giovanni Battista Di Pierro1, Caterina Gulia, Cristiano Cristini

  • 1Dipartimento di Scienze Ginecologico-Ostetriche e Scienze Urologiche, Policlinico Umberto I, Sapienza - Università di Roma.

Current Genomics
|February 2, 2013
PubMed
Summary
This summary is machine-generated.

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Bladder cancer involves complex genetic and epigenetic factors beyond FGFR3 and TP53 mutations. Genome-wide studies reveal extensive gene mis-regulation contributing to this frequent malignancy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Bladder cancer is a frequent malignancy with high recurrence rates.
  • Historically, only FGFR3 and TP53 gene alterations were thought to explain bladder cancer.
  • Tumor grading (low vs. high grade) and invasiveness are key clinical distinctions.

Purpose of the Study:

  • To review recent advancements in genome-wide analysis of bladder cancer.
  • To analyze non-genetic, genetic, and epigenetic factors contributing to gene mis-regulation.
  • To highlight the complexity of bladder cancer beyond simple genetic mutations.

Main Methods:

  • Genome-wide expression profiling studies.
  • Analysis of gene mutations (FGFR3, TP53).
  • Investigation of epigenetic modifications (DNA methylation) and non-coding RNA expression.
Keywords:
Bladder carcinomaCISFGFR3MICBNMIBCTP53carcinoma in situenvironmental causes of bladder carcinoma.epigeneticssmall non-coding RNAurinary tract

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An Orthotopic Model of Murine Bladder Cancer
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Published on: February 6, 2011

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Last Updated: May 14, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

An Orthotopic Model of Murine Bladder Cancer
09:07

An Orthotopic Model of Murine Bladder Cancer

Published on: February 6, 2011

Main Results:

  • Bladder cancer involves approximately 150 connected genes.
  • Altered gene expression affects up to 500 coding sequences in low-grade and 2300 in high-grade tumors.
  • Epigenetic changes and non-coding RNAs contribute significantly to gene mis-regulation, even without mutations in FGFR3 or TP53.

Conclusions:

  • Bladder cancer is a complex malignancy with extensive genetic and epigenetic dysregulation.
  • Beyond FGFR3 and TP53, numerous genes and regulatory mechanisms are implicated.
  • Understanding these factors is crucial for comprehending bladder cancer development and progression.