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Blood Lead in End-Stage Renal Disease (ESRD) Patients who were on Maintainence Haemodialysis

Subha Palaneeswari M1, P M Abraham Sam Rajan, Silambanan Santhi

  • 1Assistant Professor, Department of Biochemistry, Sree Balaji Medical College and Hospital , Chennai, India.

Journal of Clinical and Diagnostic Research : JCDR
|February 2, 2013
PubMed

Insights

Blood lead levels are higher in patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis (MHD). Lead concentration increases with the duration of MHD, suggesting a link between prolonged exposure and kidney disease progression.

Area of Science:

  • Nephrology
  • Environmental Health
  • Toxicology

Background:

  • Rising burden of chronic diseases like hypertension and diabetes in India.
  • Chronic kidney disease (CKD) affects 25-40% of these patients, often requiring renal replacement therapy.
  • Hemodialysis is a common treatment for end-stage renal disease (ESRD), with altered trace element metabolism reported in such patients.

Purpose of the Study:

  • To investigate blood lead levels in ESRD patients undergoing maintenance hemodialysis (MHD).
  • To determine the relationship between blood lead concentration and the duration of MHD.

Main Methods:

  • Blood lead levels were measured in 50 healthy subjects and 50 ESRD patients on MHD.
  • Subjects with a history of smoking or industrial exposure were excluded.

Main Results:

  • Blood lead levels were significantly higher in ESRD patients on MHD compared to healthy controls.
  • A positive correlation was observed between blood lead concentration and the duration of MHD.

Conclusions:

  • Elevated blood lead levels in MHD patients may be linked to prolonged exposure.
  • Chronic lead exposure, even at low levels, can contribute to CKD development and progression.
  • Lead exposure is associated with interstitial nephritis, hypertension, and cardiovascular diseases.
Abstract

Keywords:
End-stage renal diseaseLeadMaintenance haemodialysis

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