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Updated: May 14, 2026
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
Distant metastasis in triple-negative breast cancer
1Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
Neoplasma
|February 5, 2013
Summary
Triple-negative breast cancer (TNBC) survival varies by metastasis site. Lung metastases offer the best outcomes, while brain and liver metastases are linked to significantly poorer survival in TNBC patients.
Area of Science:
- Oncology
- Medical Research
- Cancer Metastasis
Background:
- Triple-negative breast cancer (TNBC) exhibits higher relapse rates and poorer prognoses compared to hormone receptor-positive subtypes.
- Understanding metastasis patterns is crucial for predicting outcomes in TNBC.
Purpose of the Study:
- To investigate the patterns of distant metastasis in TNBC patients.
- To analyze the relationship between metastasis site and overall survival (OS) in TNBC.
Main Methods:
- Retrospective analysis of 205 TNBC patients.
- Evaluation of metastasis patterns and their correlation with post-metastatic overall survival.
- Kaplan-Meier plots used for survival analysis.
Main Results:
- Lung metastases were associated with the longest median post-metastatic OS (16.6 months), followed by bone (16.3 months).
- Liver (8.9 months), pleura (7.5 months), and brain (4.3 months) metastases showed significantly poorer survival.
- Brain and liver metastases correlated with worse OS compared to bone metastases. Brain metastasis indicated the poorest survival.
Conclusions:
- The site of distant metastasis significantly impacts survival in TNBC patients.
- Lung metastasis is associated with a more favorable prognosis, whereas brain and liver metastases portend a poorer outcome.
