Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term (>5 Years) Outcomes after Magnetic Sphincter Augmentation.

Annals of surgery·2026
Same author

Reply: Molecular prognostication, response validation, and bronchoscopic intervention: The next frontiers of radiofrequency ablation.

The Journal of thoracic and cardiovascular surgery·2026
Same author

A Phase III Randomized Controlled Trial of Pyloroplasty Versus No Pyloroplasty in Patients Undergoing Minimally Invasive Esophagectomy or Robot-assisted Minimally Invasive Esophagectomy.

Annals of surgery·2025
Same author

MET alterations are enriched in lung adenocarcinoma brain metastases, defining a distinct biologic subtype.

The Journal of clinical investigation·2025
Same author

An alternative approach to repair of giant paraesophageal hernia in selected patients with minimal history of reflux: Analysis of outcomes in more than 100 patients.

JTCVS open·2025
Same author

Image-guided radiofrequency ablation for treatment of stage I non-small cell lung cancer in 111 high-risk patients: Analysis of prognostic variables.

The Journal of thoracic and cardiovascular surgery·2025

Related Experiment Video

Updated: May 14, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

Oesophageal carcinoma.

Arjun Pennathur1, Michael K Gibson, Blair A Jobe

  • 1Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Lancet (London, England)
|February 5, 2013
PubMed
Summary
This summary is machine-generated.

Oesophageal carcinoma is a growing global health concern. Early diagnosis and advances in treatment are crucial for improving the survival rates of this challenging cancer.

More Related Videos

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

Related Experiment Videos

Last Updated: May 14, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

Area of Science:

  • Oncology
  • Gastroenterology
  • Epidemiology

Background:

  • Oesophageal carcinoma impacts over 450,000 individuals globally, with a notable rise in incidence.
  • While squamous-cell carcinoma is historically predominant, adenocarcinoma is increasingly prevalent in Western countries.
  • The 5-year survival rate for oesophageal carcinoma remains low, between 15% and 25%.

Purpose of the Study:

  • To provide a comprehensive overview of oesophageal carcinoma.
  • To discuss current understanding of epidemiology, pathophysiology, and diagnosis.
  • To review management strategies, prevention, and novel treatment advancements.

Main Methods:

  • Literature review and synthesis of current research on oesophageal carcinoma.
  • Analysis of epidemiological trends and survival data.
  • Discussion of diagnostic modalities and staging systems.

Main Results:

  • Increasing global incidence of oesophageal carcinoma.
  • Shifting trends in histological types, with adenocarcinoma rising in Western nations.
  • Early diagnosis significantly correlates with improved patient outcomes.

Conclusions:

  • Oesophageal carcinoma presents a significant and growing public health challenge.
  • A multidisciplinary approach encompassing epidemiology, pathophysiology, diagnosis, and treatment is essential.
  • Continued research into prevention and treatment advances is critical for improving patient survival.