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Updated: May 14, 2026
An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
Reduced serum beta-trace protein is associated with metabolic syndrome
Ching-Lung Cheung1, Tommy T Cheung, Karen S L Lam
1Division of Clinical Pharmacology and Therapeutics, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
Objectives:
β-trace protein (BTP), also known as lipocalin-type prostaglandin D2 synthase, has shown to regulate glucose and lipid metabolism in vivo. We sought to study the relationship of serum BTP with diabetes and metabolic syndrome (MetS).
Methods:
Data on 3136 participants aged ≥20 years of the National Health and Nutrition Examination Survey III were examined. Logistic regression was used to assess the association of BTP with diabetes and MetS.
Results:
Reduced levels of BTP were associated with diabetes and MetS in age, sex, and race/ethnicity adjusted models. After further multivariable adjustment, BTP levels in quartile 1 remained significantly associated with MetS (odds ratio 2.04 [95% CI 1.14-3.70], Ptrend = 0.003) when compared with quartile 4. Among the five components of MetS, BTP was associated with hypertriglyceridemia (Ptrend < 0.001) but not diabetes (Ptrend = 0.099).
Conclusion:
MetS is associated with a reduced serum level of BTP.
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