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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
Sieving through the cancer secretome
Qifeng Lin1, Hwee Tong Tan, Hannah Soo Rei Lim
1Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117597 Singapore.
Biochimica Et Biophysica Acta
|February 5, 2013
Summary
Identifying novel cancer biomarkers from the cancer secretome is crucial for early detection. This review highlights recent advances in proteomics for analyzing cancer secretome data from six high-mortality cancers.
Area of Science:
- Oncology
- Proteomics
- Biomarker Discovery
Background:
- Cancer remains a leading global health challenge, necessitating sensitive and specific biomarkers for early detection and management.
- The cancer secretome, comprising proteins secreted by cancer cells, offers a rich source for biomarker identification due to their presence in circulation.
- Understanding the cancer secretome is vital for elucidating cancer biology and intercellular communication within the tumor microenvironment.
Purpose of the Study:
- To review recent advancements in cancer secretome analysis.
- To summarize findings from secretome studies of six high-mortality cancers: breast, colorectal, gastric, liver, lung, and prostate.
- To discuss the clinical applicability of identified cancer biomarkers.
Main Methods:
- Overview of secretome sample preparation techniques.
- Summary of data from recent proteomics-based secretome studies.
- Focus on various analytical platforms used in secretome research.
Main Results:
- Compilation of secretome data from six prevalent cancers.
- Identification of potential biomarkers with clinical relevance.
- Discussion of technological platforms employed in secretome analysis.
Conclusions:
- The cancer secretome is a valuable resource for discovering novel biomarkers.
- Proteomics technologies are advancing the study of cancer secretomes.
- Further research into the clinical utility of secretome biomarkers is warranted for improved cancer diagnostics and therapeutics.
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