[Photodynamic effects of a concanavalin A-chlorin e6 conjugate on human fibroblasts]

To minimize the side effect of porphyrin photosensitizers and to reduce their active concentration, chlorine e6 was conjugated with concanavalin A. Photodynamic action of chlorine e6 and concanavalin A-chlorine e6 conjugate has been studied in human skin embryonic fibroblasts. The conjugate appeared to be 5 times more effective as compared to chlorine e6 due to concanavalin A-chlorine e6 endocytosis into intracellular compartments.