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Role of 5α-reductase inhibitors in androgen-stimulated skin disorders

Faris Azzouni1, Nathalie Zeitouni, James Mohler

  • 1Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, USA. farisazzouni@hotmail.com

Journal of Drugs in Dermatology : JDD
|February 5, 2013
PubMed

Insights

5α-reductase (5α-R) inhibitors like finasteride treat androgen-stimulated skin disorders. This review covers their role in conditions such as male pattern baldness and the supporting clinical trials.

Area of Science:

  • Biochemistry
  • Dermatology
  • Endocrinology

Background:

  • 5α-reductase (5α-R) isozymes are crucial enzymes in human tissues.
  • These enzymes are implicated in benign prostate hyperplasia, prostate cancer, and androgen-driven skin conditions like alopecia, acne, and hirsutism.

Purpose of the Study:

  • To review the pathophysiology of androgen-stimulated skin disorders.
  • To examine key clinical trials involving 5α-R inhibitors for treating these conditions.

Main Methods:

  • Literature review of the pathophysiology of androgen-stimulated skin disorders.
  • Analysis of clinical trial data for 5α-R inhibitors (finasteride, dutasteride).

Main Results:

  • 5α-R inhibitors are FDA-approved for benign prostate hyperplasia.
  • Finasteride is FDA-approved for male androgenic alopecia.
  • The article discusses the therapeutic potential of these inhibitors.

Conclusions:

  • 5α-R inhibitors represent a significant therapeutic strategy for androgen-stimulated skin disorders.
  • Further research and clinical application are supported by existing data.

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