Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Reactions at the Benzylic Position: Halogenation01:11

Reactions at the Benzylic Position: Halogenation

Benzylic halogenation takes place under conditions that favor radical reactions such as heat, light, or a free radical initiator like peroxide.
Nomenclature of Aromatic Compounds with Multiple Substituents01:11

Nomenclature of Aromatic Compounds with Multiple Substituents

When more than one substituent is present on the benzene ring, the IUPAC nomenclature depends on the number of substituents present.
For disubstituted benzene derivatives, with two groups attached to the benzene ring, three constitutional isomers are possible. For example, consider dimethyl benzene, often called xylene, where the second methyl group can be substituted at the second, third, or fourth carbon. The relative position of the substituents is represented by prefixes ortho, meta, or...
Reactions at the Benzylic Position: Oxidation and Reduction00:59

Reactions at the Benzylic Position: Oxidation and Reduction

The benzylic position describes the position of a carbon atom attached directly to a benzene ring. Benzene by itself does not undergo oxidation. In contrast, the benzylic carbon is quite reactive in the presence of strong oxidizing agents such as KMnO4 or H2CrO4. Therefore, alkylbenzenes are readily oxidized to benzoic acid, irrespective of the type of alkyl groups.
Electrophilic Aromatic Substitution: Chlorination and Bromination of Benzene01:15

Electrophilic Aromatic Substitution: Chlorination and Bromination of Benzene

Chlorination and bromination are important classes of electrophilic aromatic substitutions, where benzene reacts with chlorine or bromine in the presence of a Lewis acid catalyst to give halogenated substitution products. A Lewis acid such as aluminium chloride or ferric chloride catalyzes the chlorination, and ferric bromide catalyzes the bromination reactions. During the bromination of alkenes, bromine polarizes and becomes electrophilic. However, in the bromination of benzene, the bromine...
NMR Spectroscopy of Benzene Derivatives01:37

NMR Spectroscopy of Benzene Derivatives

Simple unsubstituted benzene has six aromatic protons, all chemically equivalent. Therefore, benzene exhibits only a singlet peak at δ 7.3 ppm in the 1H NMR spectrum. The observed shift is far downfield because the aromatic ring current strongly deshields the protons. Any substitution on the benzene ring makes the aromatic protons nonequivalent, and the protons split each other. The peak is, therefore, no longer a singlet and the splitting pattern and their associated coupling constants depend...
Structure of Benzene: Kekulé Model01:07

Structure of Benzene: Kekulé Model

In 1865, August Kekule suggested the structure of benzene according to the structural theory of organic chemistry based on the three assertions—formula of benzene is C6H6, all the hydrogens of benzene are equivalent, and each carbon must have four bonds due to its tetravalency.
He proposed that benzene has a cyclic structure of six carbon atoms attached to one hydrogen atom each, with three alternating pi bonds.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis of a crystalline distannylene-stabilized quinoxaline radical anion.

Chemical communications (Cambridge, England)·2026
Same author

<i>N</i>-(3,5-Di-chloro-4-meth-oxy-phen-yl)acetamide.

IUCrData·2026
Same author

Synthesis of Difluoroethanols by the Unexpected Nucleophilic Addition of Lactones to Difluoromethyl Ketones and Dimerization of Difluoromethyl Ketones.

The Journal of organic chemistry·2026
Same author

HFIP-Induced Formation of <i>O</i>-Aryl Oxyallyl Cation and Nucleophilic Addition with Sodium Sulfinate Salt.

The Journal of organic chemistry·2026
Same author

Imparting Water Solubility and Aqueous Electrochemical Activity to Ferrocene upon Confinement.

Inorganic chemistry·2026
Same author

Electroanalytical Methods to Establish the Role of Buffer and Electrolyte Components in Water Denitrification Using a Copper-Based Bioinspired Electrocatalyst.

ACS measurement science au·2026

Related Experiment Video

Updated: May 14, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
08:43

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Published on: January 19, 2016

1-Chlorofuro[3,2-e][2,1,3]benzoxatellurazole.

Jennifer M Watkins1, Frank R Fronczek, Ralph A Zehnder

  • 1University of Louisiana at Monroe, Department of Chemistry, 700 University Avenue, Monroe, LA 71209, USA.

Acta Crystallographica. Section C, Crystal Structure Communications
|February 5, 2013
PubMed
Summary

This study reports a novel benzofuran-derived 2,1,3-benzoxatellurazole, featuring a planar tricyclic aromatic structure with a tellurium-carbon double bond. This discovery suggests a new reaction pathway for synthesizing related organotellurium compounds.

More Related Videos

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
08:12

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species

Published on: August 16, 2018

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
19:58

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

Related Experiment Videos

Last Updated: May 14, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
08:43

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Published on: January 19, 2016

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
08:12

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species

Published on: August 16, 2018

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
19:58

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

Area of Science:

  • Organometallic Chemistry
  • Heterocyclic Chemistry
  • Materials Science

Background:

  • Organotellurium compounds exhibit diverse chemical properties and applications.
  • Benzofuran derivatives are important scaffolds in medicinal chemistry and materials science.
  • The synthesis and characterization of novel heterocyclic tellurium compounds remain an active area of research.

Purpose of the Study:

  • To synthesize and characterize a new class of benzofuran-derived 2,1,3-benzoxatellurazole compounds.
  • To elucidate the structural features and bonding characteristics of the title compound.
  • To explore the general reactivity of 2-cyclohexenone oxime derivatives with tellurium dioxide.

Main Methods:

  • Synthesis of the title compound, C(8)H(4)ClNO(2)Te.
  • Single-crystal X-ray diffraction analysis to determine molecular structure.
  • Spectroscopic characterization (e.g., NMR, IR) and elemental analysis.

Main Results:

  • The first reported benzofuran-derived 2,1,3-benzoxatellurazole derivative was successfully synthesized.
  • Structural analysis revealed a planar tricyclic aromatic system with a tellurium-carbon double bond (Te=C).
  • Key bond lengths (Te-O: 2.1421(14) Å, Te-C: 2.0374(17) Å) were determined.

Conclusions:

  • The title compound, C(8)H(4)ClNO(2)Te, represents a unique organotellurium heterocycle.
  • The formation of this compound suggests a general synthetic route for aryl-2,1,3-benzoxatellurazoles from 2-cyclohexenone oxime derivatives and tellurium dioxide.
  • This work expands the scope of organotellurium chemistry and heterocyclic synthesis.