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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more like...

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Related Experiment Video

Updated: May 14, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening
08:14

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

Published on: October 26, 2017

MicroRNAs in the lung.

Alexandra Sittka1, Bernd Schmeck

  • 1Department of Molecular Pulmonology, Philipps-University Marburg, Marburg, Germany. alexandra.sittka@uni-marburg.de

Advances in Experimental Medicine and Biology
|February 5, 2013
PubMed
Summary
This summary is machine-generated.

MicroRNAs regulate gene expression and are crucial for lung health. This review explores their role in lung inflammation and cancer development.

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Last Updated: May 14, 2026

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Area of Science:

  • Pulmonary Medicine
  • Molecular Biology
  • Genetics

Background:

  • The lungs' large surface area is vital for gas exchange but also vulnerable to inflammatory stimuli.
  • MicroRNAs (miRNAs) are key post-transcriptional regulators influencing cellular and developmental processes.
  • miRNAs play a critical role in lung development, homeostasis, and inflammatory responses.

Purpose of the Study:

  • To review current knowledge on microRNA expression in lung inflammation.
  • To examine microRNA target regulation during lung inflammation and cancer.
  • To highlight the significance of miRNAs in pulmonary diseases.

Main Methods:

  • Literature review of studies on microRNAs in lung inflammation and cancer.
  • Analysis of current research on miRNA expression patterns.
  • Examination of miRNA-mediated gene regulation mechanisms.

Main Results:

  • miRNAs are implicated in various lung inflammatory conditions, including COPD and asthma.
  • Dysregulated miRNA expression is observed in lung cancer.
  • Specific miRNAs can target genes involved in inflammatory pathways and tumorigenesis.

Conclusions:

  • MicroRNAs are critical regulators in lung inflammation and cancer.
  • Understanding miRNA roles offers potential therapeutic targets for pulmonary diseases.
  • Further research into miRNA mechanisms is essential for advancing lung disease treatment.