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Association Between Admission Eosinophil Count and Hospital Resource Use in Community-Acquired Pneumonia: A
Barbara Christine Weckler1, Qiong Wu2, Wilhelm Bertrams3
1Department of Respiratory, Intensive Care, and Sleep Medicine, Clinic for Respiratory Infections, Marburg University, Marburg, Germany; Institute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), Marburg University, Marburg, Germany.
Chest
|April 4, 2026
Summary
Low eosinophil counts in community-acquired pneumonia (CAP) patients indicate higher hospital resource use, including intensive care unit (ICU) admission and mechanical ventilation. Eosinopenia may help predict resource needs.
Area of Science:
- Medical Research
- Pulmonology
- Clinical Biomarkers
Background:
- Eosinopenia is linked to adverse outcomes in community-acquired pneumonia (CAP).
- The association between eosinopenia and hospital resource utilization in CAP is not well understood.
Purpose of the Study:
- To investigate the relationship between admission eosinophil counts and hospital resource utilization in adult CAP patients.
Main Methods:
- A prospective, multicenter cohort study involving adult CAP patients in German university hospitals.
- Multivariable regression models assessed associations between eosinophil counts and ICU admission, mechanical ventilation, and length of stay.
- An optimal eosinophil count threshold was identified to stratify patient risk.
Main Results:
- Lower admission eosinophil counts correlated with increased ICU admission, mechanical ventilation, and longer hospital stays.
- A threshold of 10 cells/μL for eosinopenia best distinguished patients at higher risk for ICU admission and mechanical ventilation.
- Patients with eosinopenia (≤10 cells/μL) showed significantly higher rates of ICU admission, mechanical ventilation, and prolonged hospitalization.
Conclusions:
- Admission eosinopenia (≤10 cells/μL) is associated with greater hospital resource utilization in CAP.
- Eosinophil counts may serve as a practical biomarker for healthcare resource planning in CAP management.
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