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Image-guided resection of malignant gliomas using fluorescent nanoparticles
Xinhui Su1, Kai Cheng, Charlie Wang
1Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Canary Center at Stanford for Cancer Early Detection, Stanford University School of Medicine, Stanford, CA, USA.
Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|February 5, 2013
Summary
Near-infrared fluorescence (NIRF) imaging offers real-time guidance for neurosurgery, improving glioma margin definition. Novel fluorescence probes and nanoprobes enhance tumor specificity and selectivity in image-guided resections.
Area of Science:
- Neurosurgery
- Medical Imaging
- Nanotechnology
Background:
- Intraoperative fluorescence imaging, particularly near-infrared fluorescence (NIRF), shows promise for enhancing neurosurgery.
- Accurate delineation of malignant glioma margins is critical for effective surgical resection.
Purpose of the Study:
- To provide an overview of intraoperative fluorescence imaging systems and probes for glioma surgery.
- To discuss the application of various fluorescence agents, including nanoprobes, in image-guided resection of malignant gliomas.
Main Methods:
- Review of current intraoperative fluorescence imaging techniques and probes.
- Discussion of specific agents: fluorescein sodium, 5-aminolevulinic acid, dye-containing nanoparticles, and targeted NIRF nanoprobes.
- Brief consideration of photoacoustic imaging for brain tumor applications.
Main Results:
- Fluorescence imaging, especially NIRF, provides high sensitivity and real-time guidance for defining glioma margins.
- Targeted nanoprobes are being developed to improve the specificity and selectivity of tumor imaging.
- Various fluorescence probes show potential for image-guided resection of malignant gliomas.
Conclusions:
- Intraoperative fluorescence imaging, utilizing advanced probes, has the potential to significantly improve outcomes in malignant glioma surgery.
- Targeted nanoprobes represent a promising direction for enhancing the precision of image-guided tumor resection.
- Photoacoustic imaging is an emerging modality with potential for brain tumor diagnostics.
