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Published on: December 13, 2019
Assessment of left ventricular diastolic dysfunction in sub-clinical hypothyroidism
C L Meena1, R D Meena, Rajani Nawal
1Department of General Medicine, SMS Medical college, Jaipur, India.
Summary
Sub-clinical hypothyroidism is linked to diastolic dysfunction, not systolic. Early detection of this thyroid condition can help manage cardiovascular risks.
Area of Science:
- Cardiology
- Endocrinology
- Medical Diagnostics
Background:
- Hypothyroidism is associated with adverse cardiovascular effects.
- Early identification of sub-clinical hypothyroidism may improve cardiovascular outcomes.
- Sub-clinical hypothyroidism poses a risk for cardiovascular morbidity and mortality.
Purpose of the Study:
- To investigate the association between sub-clinical hypothyroidism and left ventricular dysfunction.
- To determine the relationship between systolic and diastolic dysfunction in patients with sub-clinical hypothyroidism.
Main Methods:
- Study included 30 patients with sub-clinical hypothyroidism and 15 healthy controls.
- Serum TSH, T4, and T3 levels were measured.
- Two-dimensional echocardiography (2DEcho) was performed on patients with sub-clinical hypothyroidism.
Main Results:
- Significant reductions in early filling velocities (PE, Ei) and related ratios (PE/PA, Ei/Ai, PE/M) were observed.
- Mean ejection fraction (EF) showed no significant difference between hypothyroid patients and controls.
- Significant diastolic dysfunction was evident in hypothyroid patients (mean Ei/Ai = 1.35 ± 0.53) compared to controls (mean Ei/AI = 2.11 ± 0.26).
Conclusions:
- Sub-clinical hypothyroidism is associated with significant diastolic dysfunction.
- Systolic function remains largely unimpaired in the presence of sub-clinical hypothyroidism.
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