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Related Concept Videos

Histology of the Small Intestine01:27

Histology of the Small Intestine

The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

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Related Experiment Video

Updated: May 14, 2026

Tissue Engineering of the Intestine in a Murine Model
08:45

Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

Tissue engineering the small intestine.

Ryan G Spurrier1, Tracy C Grikscheit

  • 1Division of Pediatric Surgery, Children's Hospital Los Angeles, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|February 6, 2013
PubMed
Summary
This summary is machine-generated.

Tissue-engineered small intestine (TESI) offers a promising solution for short bowel syndrome (SBS). TESI, grown from patient cells, restores intestinal function and improves outcomes in animal models, paving the way for human therapies.

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Last Updated: May 14, 2026

Tissue Engineering of the Intestine in a Murine Model
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Published on: December 1, 2012

A Decellularization Methodology for the Production of a Natural Acellular Intestinal Matrix
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Published on: October 7, 2013

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
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Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Published on: February 10, 2020

Area of Science:

  • Regenerative Medicine
  • Gastroenterology
  • Biomedical Engineering

Background:

  • Short bowel syndrome (SBS) significantly impacts patient morbidity and mortality.
  • Current treatments for SBS are limited and carry substantial risks.
  • Autologous tissue engineering presents a potential solution to restore intestinal function.

Purpose of the Study:

  • To investigate the feasibility of producing tissue-engineered small intestine (TESI) for treating SBS.
  • To evaluate the potential of TESI for autologous transplantation and restoration of intestinal function.

Main Methods:

  • TESI production involves harvesting organoid units from native intestine.
  • Organoid units are loaded onto a scaffold and implanted in vivo for development.
  • Scaffolds support angiogenesis and vasculogenesis, facilitating tissue maturation.

Main Results:

  • Histological analysis shows TESI closely resembles native intestine after 4 weeks.
  • TESI contains differentiated epithelium, mesenchyme, vasculature, muscle, and nerve components.
  • Successful implantation and functional improvement observed in rat, mouse, and pig models of SBS.

Conclusions:

  • TESI shows promise for treating SBS, with successful preclinical trials in multiple animal models.
  • TESI transplantation led to improved weight gain and B12 levels in SBS rats.
  • Advancements in stem cell biology and tissue engineering are crucial for translating TESI to human therapy.