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Updated: May 14, 2026

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
05:39

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Published on: July 8, 2020

Interferon-alpha for IgM nephropathy?

Sha Liu, Dongliang Zhang, Qidong Zhang

    Clinical Nephrology
    |February 6, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Immunoglobulin M (IgM) nephropathy often leads to kidney failure. A patient with nephrotic syndrome experienced long-term remission of IgM nephropathy using sustained interferon-alpha treatment, offering a potential new therapy.

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    Last Updated: May 14, 2026

    Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
    05:39

    Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

    Published on: July 8, 2020

    Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
    08:26

    Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

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    High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
    10:00

    High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

    Published on: March 24, 2015

    Area of Science:

    • Nephrology
    • Immunology
    • Internal Medicine

    Background:

    • Immunoglobulin M (IgM) nephropathy is a kidney disease marked by IgM deposits in the glomeruli.
    • It often presents with nephrotic syndrome and frequently progresses to end-stage renal disease, lacking effective long-term treatments.

    Observation:

    • A patient with recurrent nephrotic syndrome due to IgM nephropathy was treated.
    • The patient received sustained interferon-alpha therapy.

    Findings:

    • The patient achieved long-term remission of nephrotic syndrome.
    • This suggests interferon-alpha may be an effective treatment for IgM nephropathy.

    Implications:

    • Sustained interferon-alpha treatment represents a potential therapeutic alternative for patients with IgM nephropathy.
    • Further research is warranted to explore interferon-alpha's efficacy and safety in a larger cohort.