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Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Updated: May 14, 2026

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells
04:23

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells

Published on: March 31, 2021

Engineering stem cells for future medicine.

Leonardo Ricotti1, Arianna Menciassi

  • 1BioRobotics Institute, Scuola Superiore Sant'Anna, Pontedera 56025, Italy. l.ricotti@sssup.it

IEEE Transactions on Bio-Medical Engineering
|February 6, 2013
PubMed
Summary
This summary is machine-generated.

Bioengineering advances stem cell therapy by improving functional maturation and delivery. This research explores challenges, benefits, and future technologies like robotics for safe clinical translation of stem cells.

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Area of Science:

  • Regenerative Medicine
  • Bioengineering
  • Stem Cell Biology

Background:

  • Stem cells show great potential in regenerative medicine but face limited clinical success.
  • Current limitations stem from insufficient biological knowledge and inadequate technological tools for stem cell maturation and delivery.

Purpose of the Study:

  • To review recent insights, limitations, and future directions in therapeutic stem cell applications.
  • To analyze how bioengineering disciplines can enhance stem cell functional maturation and safe clinical translation.

Main Methods:

  • Exploration of stem cell engineering strategies, including chemical, mechanical, topographical, and physical stimulation for differentiation and maturation.
  • Discussion of multiscale modeling's role in optimizing stem cell engineering.
  • Focus on future robotic tools for advanced stem cell delivery and control.

Main Results:

  • Identified key bioengineering approaches to overcome stem cell functional maturation barriers.
  • Highlighted the potential of multiscale modeling to refine stem cell engineering processes.
  • Emphasized the role of robotics in enabling precise stem cell delivery and control for clinical applications.

Conclusions:

  • Bioengineering is crucial for advancing stem cell therapy towards safe and effective clinical use.
  • Future technological developments, particularly in robotics and modeling, will be vital for translating stem cell potential into tangible therapeutic benefits.