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Updated: May 14, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
Published on: July 14, 2015
A novel structural tree for wrap-proteins, a subclass of (α+β)-proteins
Eugenia A Boshkova1, Alexey B Gordeev, Alexander V Efimov
1a Institute of Protein Research, Russian Academy of Sciences , Pushchino , Moscow Region , 142290 , Russian Federation .
Abstract:
In this paper, a novel structural subclass of (α+β)-proteins is presented. A characteristic feature of these proteins and domains is that they consist of strongly twisted and coiled β-sheets wrapped around one or two α-helices, so they are referred to here as wrap-proteins. It is shown that overall folds of the wrap-proteins can be obtained by stepwise addition of α-helices and/or β-strands to the strongly twisted and coiled β-hairpin taken as the starting structure in modeling. As a result of modeling, a structural tree for the wrap-proteins was constructed that includes 201 folds of which 49 occur in known nonhomologous proteins.
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