Related Experiment Video

Updated: May 14, 2026

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
09:20

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

The role of ADAM17 in metabolic inflammation

Rossella Menghini1, Loredana Fiorentino, Viviana Casagrande

  • 1Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

Atherosclerosis
|February 7, 2013
PubMed

Insights

The TNF-alpha Converting Enzyme (TACE), or ADAM17, cleaves proteins involved in cell signaling. This review explores ADAM17's role in metabolic tissues, impacting conditions like diabetes and atherosclerosis.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Metabolic Research

Background:

  • ADAM17 (A Disintegrin and A Metalloproteinase 17), also known as TACE, is a metalloproteinase.
  • It mediates the shedding of various transmembrane proteins, influencing cell signaling pathways.
  • ADAM17 is implicated in inflammatory disorders and metabolic diseases.

Purpose of the Study:

  • To review the role of ADAM17 in major metabolic tissues.
  • To highlight ADAM17's involvement in atherosclerosis, adipose tissue metabolism, insulin resistance, and diabetes.

Main Methods:

  • Literature review of studies on ADAM17 function.
  • Analysis of ADAM17 substrate cleavage and its physiological consequences.
  • Focus on ADAM17's impact on key metabolic tissues.

Main Results:

  • ADAM17 participates in regulated intramembrane proteolysis, affecting intracellular signaling.
  • Evidence links ADAM17 activity to the pathogenesis of atherosclerosis.
  • ADAM17 plays a significant role in adipose tissue metabolism and insulin resistance.

Conclusions:

  • ADAM17 is a critical enzyme in metabolic regulation.
  • Targeting ADAM17 may offer therapeutic strategies for metabolic and inflammatory diseases.
  • Further research into ADAM17 substrates and functions in metabolic tissues is warranted.

More Related Videos

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance09:48

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

Isolation and Culture of Human Mature Adipocytes Using Membrane Mature Adipocyte Aggregate Cultures (MAAC)06:28

Isolation and Culture of Human Mature Adipocytes Using Membrane Mature Adipocyte Aggregate Cultures (MAAC)

Published on: February 13, 2020

Related Concept Videos

Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...