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Related Concept Videos

Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...

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Updated: May 14, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

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Published on: November 30, 2016

Irritable bowel syndrome--diarrhoea.

Arnold Wald1

  • 1Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, Suite 4000, Madison, WI 53705, USA. axw@medicine.wisc.edu

Best Practice & Research. Clinical Gastroenterology
|February 7, 2013
PubMed
Summary

Irritable Bowel Syndrome with Diarrhea (IBS-D) affects one-third of patients. Management requires addressing the biopsychosocial nature of IBS-D beyond just altered bowel habits.

Area of Science:

  • Gastroenterology
  • Clinical Medicine

Background:

  • Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder.
  • IBS is subtyped based on predominant bowel habits.
  • IBS with Diarrhea (IBS-D) constitutes approximately one-third of all IBS cases.

Purpose of the Study:

  • To provide evidence-based recommendations for the management of IBS-D.
  • To highlight the biopsychosocial complexity of IBS-D.
  • To outline various therapeutic strategies for IBS-D.

Main Methods:

  • This is a review article.
  • Evidence for different treatment modalities is presented.
  • Focus is on dietary manipulations, probiotics, and pharmacotherapies.

Main Results:

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  • IBS-D is characterized by loose or watery stools in at least 25% of bowel movements.
  • Treatment should encompass the biopsychosocial aspects of the condition.
  • Multiple treatment options are available, including dietary changes, probiotics, and various medications.

Conclusions:

  • Effective management of IBS-D requires a comprehensive approach.
  • Therapeutic strategies include dietary interventions, probiotics, and pharmacotherapy.
  • Pharmacotherapies discussed include tricyclic agents, antibiotics, serotonin antagonists, and anti-diarrheal agents.