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Related Concept Videos

Protein Families02:47

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Signal Sequences and Sorting Receptors01:41

Signal Sequences and Sorting Receptors

Signal sequences are short amino acid sequences that guide newly synthesized proteins to their proper location within the cell. Classical signal sequences are fifteen to sixty amino acids long and present at the N-terminus of a polypeptide chain. Each signal sequence has a conserved segment of basic residues towards their N terminus, a hydrophobic core, and a C-terminus rich in polar residues. The C-terminus also contains a signal cleavage site and features a -3 -1 sequence motif. The -3-1...
Conservation of Protein Domains02:26

Conservation of Protein Domains

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...

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Related Experiment Video

Updated: May 14, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

An algorithm to find all palindromic sequences in proteins.

N Prasanth1, M Kirti Vaishnavi, K Sekar

  • 1Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560 012.

Journal of Biosciences
|February 7, 2013
PubMed
Summary
This summary is machine-generated.

Researchers developed a new algorithm to find perfect palindromic peptide sequences within protein sequences. This tool helps uncover the structural, functional, and evolutionary roles of these unique sequence patterns.

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DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling
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DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling

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Last Updated: May 14, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling
08:04

DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling

Published on: October 8, 2019

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Structural Biology

Background:

  • Palindromic peptide sequences, reading the same forwards and backwards, were discovered two decades ago.
  • Limited research has explored the structural, functional, and evolutionary significance of these palindromic sequences.
  • Identifying palindromes in protein sequences is challenging due to their varied nature.

Purpose of the Study:

  • To develop an advanced algorithm for identifying perfect palindromic peptide sequences in protein data.
  • To provide a tool that can detect palindromes of any length within a single protein sequence.
  • To facilitate further research into the significance of palindromic sequences in proteins.

Main Methods:

  • An algorithm was designed to detect all perfect palindromic sequences.
  • The algorithm excludes palindromic subsets and tandem repeats for precise identification.
  • The method is applicable to protein sequences of any length, without restrictions.

Main Results:

  • The algorithm successfully identifies perfect palindromic peptide sequences.
  • It can detect palindromes of varying lengths within a single protein sequence.
  • The developed tool offers a comprehensive approach to palindrome identification.

Conclusions:

  • The new algorithm provides a robust method for finding palindromic peptide sequences.
  • This tool will aid in understanding the structural, functional, and evolutionary roles of palindromes.
  • Further investigation into palindromic sequences is now more feasible.