Related Experiment Video
Updated: May 14, 2026
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Lupus nephritis: a 15-year multi-centre experience in the UK
1Department of Rheumatology, Nottingham University Hospitals NHS Trust, UK. mhui@nhs.net
Lupus
|February 7, 2013
Summary
Lupus nephritis (LN) outcomes in the East Midlands were comparable to European studies. Vigilance for LN is crucial, as flares can occur years after systemic lupus erythematosus (SLE) diagnosis, especially in partial responders.
Area of Science:
- Nephrology
- Rheumatology
- Immunology
Background:
- Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE).
- Understanding treatment outcomes and long-term prognosis is vital for patient management.
- Audit data from regional centers can provide valuable insights into real-world effectiveness.
Purpose of the Study:
- To audit the outcomes of lupus nephritis (LN) across three East Midlands centers.
- To evaluate treatment response, flare rates, and end-stage renal failure in LN patients.
- To compare observed outcomes with existing European clinical studies.
Main Methods:
- Retrospective review of biopsy-proven lupus nephritis (LN) types III-V.
- Data collected from 1995 to 2010 across three East Midlands centers.
- Analysis of induction and maintenance therapies, treatment responses, and long-term outcomes.
Main Results:
- 61 patients with LN were identified, with a median follow-up of 68 months.
- Induction therapy with IV cyclophosphamide or mycophenolate mofetil (MMF) showed high initial response rates (over 81%).
- 32.8% experienced flares post-induction, with partial responders having significantly higher flare rates (43.8%) than complete responders (4.8%); 8.2% developed end-stage renal failure.
Conclusions:
- Outcomes for lupus nephritis (LN) in the East Midlands are comparable to European studies.
- Partial responders to induction therapy are at higher risk of experiencing flares.
- Continued vigilance for LN is essential, as it can manifest or flare years after SLE diagnosis.
Related Concept Videos
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
01:24Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
01:29Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
01:26Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
01:28Chronic Kidney Disease III: Interprofessional Care
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
01:22Acute Kidney Injury I: Introduction
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...