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Updated: May 14, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
High expression of epidermal growth factor receptor might predict poor survival in patients with colon cancer: a
Liu Hong1, Yu Han, Hongwei Zhang
1Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China. hongliu180@126.com
Background And Aims:
The epidermal growth factor receptor (EGFR) has been recognized as a molecular target for antibody-based therapy in various cancer types. Here we aimed to analyze the relation between high expression of EGFR and postoperational survival in patients with colon cancer.
Methods:
A meta-analysis was performed by searching PubMed, Cochrane Library, EMBASE, and Science Direct databases from 1960 to June 2012. Data were extracted from studies comparing survival in colon cancer patients having higher EGFR expression with those having lower levels. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated.
Results:
Four studies including 815 colon cancer patients were subjected to final analysis. Comparing to patients with low expression of EGFR, the HR of postoperational survival for patients with high EGFR expression was 2.34 (95% CI: 1.83-2.99), which could significantly predict poorer survival.
Conclusions:
High expression of EGFR might predict poor survival for patients with colon cancer.
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