[Some features of the modeling and age differences of the course of acute experimental peritonitis]

Investigations were carried out on 24 white Wistar rats which, depending on age were divided into two groups: the first 6 months, the other 12 months. Using the priority method of autointestine (20% mixture of the colon at the rate of 1.0 ml per 100 g of weight of test animal) modeling peritonitis enabled reproduce the disease process adequately and set the age differences. In experimental animals 12 months of peritonitis 18 hours, as opposed to six month, it has been a significant deterioration in hemodynamics with reduction of systolic blood pressure to 83,18±2,98 mm.Hg and diastolic blood pressure up to 64,59±5,43 mm.Hg. In addition, there has been differences in the toxicity of enteric contents, as evidenced by the decrease in pH to 4,06±0,28 and reducing the time paramecium test to 3,12±0,14 minutes. The results of experimental studies have also been installed significant age differences transintestinal redistribution of toxic substances. The 12 month animals predominate intestine-portal contamination, which was expressed in increasing concentration of AMW-280 and 0,45±0,03 S.U., LII to 2,58±0,11 and lower Paramecium test to 5,44±0,26 minutes. Thereby, the modeling of experimental peritonitis of 18 hours there were significant age differences in the pace and extent redistribution of contamination processes that lead to the aggravation of the generalization of the pathological process, which requires the development of modern methods of intra-operative intra-abdominal correction.