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Updated: May 14, 2026

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice
Published on: December 18, 2015
Tracking cells in their native habitat: lineage tracing in epithelial neoplasia
Maria P Alcolea1, Philip H Jones
1MRC Cancer Cell Unit, Cambridge CB2 0XZ, UK.
Abstract:
For tumours to develop, mutations must disrupt tissue homeostasis in favour of deregulated proliferation. Genetic lineage tracing has uncovered the behaviour of proliferating cells that underpins the maintenance of epithelial tissues and the barriers that are broken in neoplastic transformation. In this Review, we focus on new insights revealed by quantifying the behaviour of normal, preneoplastic and tumour cells in epithelia in transgenic mice and consider their potential importance in humans.
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