Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of a Thermostable Nigerose Phosphorylase for the Efficient Chemoenzymatic Radiosynthesis of a <i>S. aureus</i>-Targeted <sup>18</sup>F-Disaccharide.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Dose calculation accuracy with extended CT scales near metal: phantom-patient evaluation using a beam-metal overlap metric.

Radiation oncology (London, England)·2026
Same author

Heterogeneous Iron-Catalyzed Borylation of Aryl Fluorides.

The Journal of organic chemistry·2026
Same author

Correction to "Iron-Catalyzed Borylation of Aryl Trifluoromethoxides".

Organic letters·2025
Same author

Discrete Cation Exchange in Ag-Au-S Quantum Dots Using Reactivity Engineered Cation Precursors.

ACS nano·2025
Same author

Bench-Stable Copper Complex for Trifluoromethylation and <sup>18</sup>F-Labeling of Aryl Iodides.

Organic letters·2025

Related Experiment Video

Updated: May 14, 2026

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
12:54

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

Adaptive optical probe design for optical coherence tomography and microscopy using tunable optics.

Minseog Choi1, Seungwan Lee, Jong-Hyeon Chang

  • 1Micro Systems Laboratory, Samsung Advanced Institute of Technology, San 14, Nongseo-dong, Giheung-gu, Yongin-si, Gyeonggi-do 446-712, South Korea. minseog@samsung.com

Optics Express
|February 8, 2013
PubMed
Summary

We developed a new adaptive optical imaging probe for multimodal imaging, like optical coherence tomography and microscopy. This versatile probe offers three distinct imaging modes with adjustable resolution and depth for enhanced visualization.

More Related Videos

Automated 3D Optical Coherence Tomography to Elucidate Biofilm Morphogenesis Over Large Spatial Scales
09:56

Automated 3D Optical Coherence Tomography to Elucidate Biofilm Morphogenesis Over Large Spatial Scales

Published on: August 21, 2019

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)
12:22

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Related Experiment Videos

Last Updated: May 14, 2026

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
12:54

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

Automated 3D Optical Coherence Tomography to Elucidate Biofilm Morphogenesis Over Large Spatial Scales
09:56

Automated 3D Optical Coherence Tomography to Elucidate Biofilm Morphogenesis Over Large Spatial Scales

Published on: August 21, 2019

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)
12:22

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Area of Science:

  • Biomedical Optics
  • Optical Engineering
  • Medical Imaging

Background:

  • Multimodal optical imaging offers enhanced diagnostic capabilities.
  • Existing endoscopic imaging probes have limitations in adaptability and resolution.
  • Need for advanced probes compatible with forward-looking scanning laser devices.

Purpose of the Study:

  • To present a novel tunable, adaptive optical imaging probe.
  • To enable multimodal imaging modalities including optical coherence tomography and microscopy.
  • To ensure compatibility with forward-looking scanning laser imaging devices like endoscopes.

Main Methods:

  • The probe incorporates a tunable iris and two microelectrofluidic-driven varifocal lenses.
  • Conventional fixed focus lenses are integrated into the optical configuration.
  • Optical simulations were employed to evaluate performance metrics.

Main Results:

  • The modulation transfer function and focal plane spot size were assessed.
  • Optical simulations revealed three distinct imaging modes.
  • These modes offer variations in transverse resolution and focal depth.

Conclusions:

  • The developed probe provides tunable and adaptive imaging capabilities.
  • It supports multimodal imaging and is compatible with endoscopic devices.
  • The probe's design allows for flexible optimization of imaging parameters.