Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 14, 2026

Visualizing Diffusional Dynamics of Gold Nanorods on Cell Membrane using Single Nanoparticle Darkfield Microscopy
09:09

Visualizing Diffusional Dynamics of Gold Nanorods on Cell Membrane using Single Nanoparticle Darkfield Microscopy

Published on: March 5, 2021

Subcutaneous gold nanorods [corrected] detection with diffusion reflection measurement.

Dror Fixler1, Rinat Ankri

  • 1Bar-Ilan University, Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Ramat-Gan 52900, Israel. Dror.Fixler@biu.ac.il

Journal of Biomedical Optics
|February 8, 2013
PubMed
Summary

This study presents a new noninvasive method using diffusion reflection to quantify gold nanorod (GNR) concentration in tissue. This technique shows promise for in vivo cancer diagnostics using nanoparticles.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Light sources and detectors: applications in nanoscale imaging, sensing, and actuation.

Journal of biomedical optics·2026
Same author

Reduce hypoxemia overestimation in pulse oximetry based on iso-pathlength: a Monte Carlo study.

Optics letters·2026
Same author

Endoscopic iso-pathlength self-calibration for direction-resolved retrieval of tissue optical properties.

Journal of biomedical optics·2026
Same author

Phase analysis method for characterizing absorption in turbid media: theory, simulations, and TiO<sub>2</sub> phantom experiments.

Optics express·2026
Same author

Pavlov's experiment-inspired optical neural networks based on dual-color fluorescence switching effect.

National science review·2026
Same author

Impact of analyzer angle and tube geometry on the iso-pathlength point in polarization-resolved measurements of scattering media.

Optics express·2026

Area of Science:

  • Biomedical Optics
  • Nanotechnology
  • Medical Imaging

Background:

  • Noninvasive detection of nanoparticles near the skin is crucial for in vivo cancer diagnostics.
  • Diffusion reflection (DR) is a noninvasive imaging technique for assessing tissue optical properties.

Purpose of the Study:

  • To develop and validate a novel method for quantifying gold nanorod (GNR) concentration in tissue-like phantoms.
  • To explore the application of DR measurements combined with GNR's light absorption properties.

Main Methods:

  • Utilized diffusion reflection (DR) measurements.
  • Employed Monte Carlo simulations and phantom experiments.
  • Investigated intense light absorption by gold nanorods (GNRs).

Main Results:

More Related Videos

Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods
10:46

Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods

Published on: May 2, 2016

Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
09:11

Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications

Published on: March 22, 2020

Related Experiment Videos

Last Updated: May 14, 2026

Visualizing Diffusional Dynamics of Gold Nanorods on Cell Membrane using Single Nanoparticle Darkfield Microscopy
09:09

Visualizing Diffusional Dynamics of Gold Nanorods on Cell Membrane using Single Nanoparticle Darkfield Microscopy

Published on: March 5, 2021

Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods
10:46

Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods

Published on: May 2, 2016

Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
09:11

Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications

Published on: March 22, 2020

  • Successfully demonstrated the extraction of optical properties from phantoms using DR measurements.
  • Quantified gold nanorod (GNR) concentrations in tissue-like phantoms.
  • Validated the feasibility of the DR method for GNR detection.

Conclusions:

  • The presented DR-based method enables quantitative, noninvasive detection of gold nanorods (GNRs) in tissue-like phantoms.
  • This technique holds potential for advancing in vivo cancer diagnostics.
  • Further discussion on optimal light propagation models in tissues was provided.