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Isolation and Activation of Murine Lymphocytes
Published on: October 30, 2016
Proliferation activity in canine lymphomas.
J Sokołowska1, J Micun, E Malicka
1Department of Morphological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159c, 02-776 Warsaw, Poland. justynasok@interia.pl
Polish Journal of Veterinary Sciences
|February 9, 2013
Summary
Canine lymphomas show high proliferation activity, with Ki67 expression and mitotic index correlating strongly. Assessing proliferation aids in selecting canine lymphoma treatments.
Area of Science:
- Veterinary Pathology
- Oncology
- Immunohistochemistry
Background:
- Canine lymphomas are common, and their classification is crucial for prognosis and treatment.
- Proliferation markers like Ki67 and mitotic index (MI) are important indicators of tumor aggressiveness.
Purpose of the Study:
- To evaluate the proliferation activity in canine lymphomas using Ki67 expression and mitotic index.
- To determine the correlation between Ki67 and MI in different canine lymphoma subtypes.
- To assess the utility of proliferation markers in guiding treatment decisions for canine lymphoma.
Main Methods:
- Classified 45 canine lymphomas (14 T-cell, 28 B-cell, 3 null-cell) using the updated Kiel classification.
- Quantified Ki67-positive cells and mitotic index (MI) in each lymphoma specimen.
- Analyzed the correlation between Ki67 expression and MI, and compared values across different lymphoma types.
Main Results:
- Most lymphomas (39/45) exhibited high proliferation activity.
- A significant positive correlation was found between Ki67 expression and MI (r=0.668).
- T-cell lymphomas showed a higher mean MI than B-cell lymphomas (4.30 vs. 3.33).
Conclusions:
- Proliferation activity, assessed by Ki67 and MI, varies significantly in canine lymphomas.
- The strong correlation between Ki67 and MI supports their use as prognostic indicators.
- Assessing proliferation activity is valuable for selecting appropriate treatment strategies in canine lymphoma cases.
