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Related Concept Videos

Gross Anatomy of Bone01:17

Gross Anatomy of Bone

The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Structure01:55

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Updated: May 14, 2026

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation
07:00

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation

Published on: August 23, 2018

Marrow fat and bone--new perspectives.

Pouneh K Fazeli1, Mark C Horowitz, Ormond A MacDougald

  • 1Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

The Journal of Clinical Endocrinology and Metabolism
|February 9, 2013
PubMed
Summary
This summary is machine-generated.

Marrow adipose tissue is inversely associated with bone density and strength. Further research is needed to understand its functional role in skeletal integrity and bone loss.

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Area of Science:

  • Endocrinology
  • Bone Biology
  • Metabolic Diseases

Background:

  • Growing interest in the relationship between bone health and fat depots.
  • Marrow adipose tissue (MAT) is a distinct component of the bone marrow environment.
  • The functional significance of MAT remains largely unknown.

Purpose of the Study:

  • To review animal and human data on MAT and bone density/integrity.
  • To explore MAT's significance in metabolic diseases linked to bone loss (e.g., type 1 diabetes, anorexia nervosa).
  • To discuss potential hormonal determinants of MAT.

Main Methods:

  • Literature review of animal and human studies.
  • Analysis of data linking MAT to bone parameters.
  • Discussion of metabolic disease associations and hormonal influences.

Main Results:

  • Most data show an inverse association between MAT and bone density/strength.
  • MAT may play a role in metabolic diseases associated with bone loss.
  • Hormonal determinants of MAT are under investigation.

Conclusions:

  • An inverse relationship between MAT and bone health is generally observed.
  • Understanding MAT's functional role and hormonal regulation is crucial.
  • Further research is needed to clarify MAT's role in skeletal integrity and bone pathophysiology.