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Related Concept Videos

Decision Making: P-value Method01:09

Decision Making: P-value Method

The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim  is also stated. These statements can act as null and alternative hypotheses:  a null hypothesis would be a neutral statement while the alternative hypothesis can have a...
Methods of Documentation III: PIE01:21

Methods of Documentation III: PIE

Problem-intervention-evaluation (PIE) is a systematic approach to documentation used in healthcare settings for clinical decision-making and patient care planning. It is a structured approach to organizing patient data based on problems, interventions, and evaluations. Here's a breakdown of its key features and considerations:
P-value01:10

P-value

P-value is one of the most crucial concepts in statistics.
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A large P-value calculated from the data indicates to  not reject the null hypothesis. But a higher P-value does not mean that the null hypothesis is true. The smaller the P-value, the more unlikely...
Methods of Documentation II: POMR01:26

Methods of Documentation II: POMR

The Problem-Oriented Medical Record (POMR) revolutionized medical record-keeping by introducing a systematic approach focusing on the patient's problems rather than merely listing symptoms. Dr. Lawrence Weed's introduction of this method in the 1960s marked a significant advancement in medical documentation. The POMR framework consists of four key components: the database, problem list, plan of care, and progress notes.
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
pV-Diagrams01:18

pV-Diagrams

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Related Experiment Video

Updated: May 14, 2026

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

Expect p&t committees to demand more data.

Scott Kober

    Biotechnology Healthcare
    |February 9, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Recent drug withdrawals may lead to increased scrutiny of novel biologics and breakthrough therapies by formulary committees. Pharmacy and Therapeutics (P&T) members will likely increase their questioning before approving these advanced treatments.

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    Area of Science:

    • Pharmaceutical policy
    • Drug evaluation
    • Health economics

    Background:

    • High-profile drug withdrawals have raised concerns regarding the safety and efficacy of novel therapeutics.
    • Formulary committees play a critical role in drug approval and access decisions.

    Purpose of the Study:

    • To assess the potential impact of drug withdrawals on the perception and approval process of biologics and breakthrough therapies by Pharmacy and Therapeutics (P&T) committees.
    • To understand how P&T members' questioning and scrutiny might change for innovative drug products.

    Main Methods:

    • Qualitative analysis of formulary committee member sentiment.
    • Review of recent drug withdrawal data and its correlation with P&T meeting minutes.
    • Expert interviews with formulary decision-makers.

    Main Results:

    • Formulary committees are expected to exhibit increased skepticism towards biologics and breakthrough therapies following significant drug withdrawals.
    • P&T members are likely to pose more in-depth questions regarding clinical evidence, safety profiles, and comparative effectiveness.

    Conclusions:

    • Past drug withdrawals may necessitate a more rigorous and cautious approach by P&T committees when evaluating novel and high-impact medications.
    • Future drug development and approval processes may need to address heightened scrutiny for innovative therapies.