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Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
Fulminant type 1 diabetes mellitus: a new class of type 1 diabetes
Saeko Shibasaki1, Akihisa Imagawa, Toshiaki Hanafusa
1Department of Internal Medicine (I), Osaka Medical College, Takatsuki, Osaka, Japan.
Abstract:
Fulminant Type 1 diabetes is a novel subtype of Type 1 diabetes. In this disease, extremely rapid and almost complete beta-cell destruction occurs, resulting in nearly no residual insulin secretion even just after the onset. The number of patients presumably amounts to 5,000-7,000 in Japan. The involvement of both, genetic background and viral infection, has been suggested in the pathogenesis of this disease. Diagnostic criteria were established by a committee of the Japan Diabetes Society in 2004. Intensive insulin therapy is a standard therapy. We should pay special attention to early development of microvascular complications in fulminant Type 1 diabetes.
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