Related Experiment Video

Updated: Jan 31, 2026

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
10:52

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence

Published on: December 23, 2022

5.8K

Elevated left ventricular end-diastolic pressure favours closure of foramen ovale

Federico Landeta1, Elmar von dem Bussche, Martin Ritter

  • 1Department of Cardiology and Angiology, University Hospital Muenster, Germany. flandeta@yahoo.com.ar

Acta Cardiologica
|February 12, 2013
PubMed

Insights

Persistent high left atrial pressures, not age, may influence patent foramen ovale (PFO) closure. Elevated left ventricular end-diastolic pressures (LVEDP) were linked to a lower PFO prevalence in patients with suspected cardioembolic stroke.

Area of Science:

  • Cardiology
  • Cardiovascular Research
  • Medical Diagnostics

Background:

  • Patent foramen ovale (PFO) is a common cardiac anomaly.
  • Previous studies suggested PFO prevalence decreases with age.
  • The relationship between left atrial pressure and PFO closure requires further investigation.

Purpose of the Study:

  • To test the hypothesis that elevated left atrial (LA) pressures facilitate PFO closure.
  • To investigate the role of age in PFO prevalence.
  • To identify factors associated with PFO in patients with suspected cardioembolic stroke.

Main Methods:

  • Contrast transesophageal echocardiography was used to assess PFO prevalence in 201 patients.
  • Non-invasive transthoracic echocardiography estimated left ventricular end-diastolic pressures (LVEDP).
  • Diastolic function (DF) and diastolic dysfunction (DD) stages were used to categorize LVEDP as normal or elevated.

Main Results:

  • PFO prevalence was 42.8% overall.
  • Patients with elevated LVEDP (DD stage II/III) had significantly lower PFO prevalence (21.2%) compared to those with normal LVEDP (51.7%).
  • LA size was larger in patients without PFO, and age was not associated with PFO prevalence.

Conclusions:

  • Elevated LVEDP and LA enlargement are negatively associated with PFO.
  • Higher LVEDP correlates with a lower prevalence of PFO.
  • Age does not play a significant role in PFO prevalence.
Abstract

More Related Videos

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

4.3K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.9K

Related Concept Videos

Elevation of Intermediate Points on Vertical Curves01:20

Elevation of Intermediate Points on Vertical Curves

Vertical curves are essential in roadway design because they provide smooth transitions between varying roadway grades. Designing vertical curves involves calculating intermediate elevations and identifying the curve's highest or lowest point, which is essential for optimal roadway performance.Intermediate elevations on a vertical curve are determined using the tangent offset method. This method considers the initial elevation at the start of the curve, the grades, and the curve's geometry. The...
289
Freezing Point Depression and Boiling Point Elevation03:12

Freezing Point Depression and Boiling Point Elevation

Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.0K
Gibbs Free Energy and Thermodynamic Favorability02:23

Gibbs Free Energy and Thermodynamic Favorability

The spontaneity of a process depends upon the temperature of the system. Phase transitions, for example, will proceed spontaneously in one direction or the other depending upon the temperature of the substance in question. Likewise, some chemical reactions can also exhibit temperature-dependent spontaneities. To illustrate this concept, the equation relating free energy change to the enthalpy and entropy changes for the process is considered:
8.2K
Definition and Measurement of Pressure: Atmospheric Pressure, Barometer, and Manometer02:57

Definition and Measurement of Pressure: Atmospheric Pressure, Barometer, and Manometer

Gas pressure is caused by force exerted by gas molecules colliding with the surfaces of objects. Although the force of each collision is very small, any surface of an appreciable area experiences a large number of collisions in a short time, which can result in high pressure.
43.3K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.3K
Vapor Pressure02:34

Vapor Pressure

When a liquid vaporizes in a closed container, gas molecules cannot escape. As these gas phase molecules move randomly about, they will occasionally collide with the surface of the condensed phase, and in some cases, these collisions will result in the molecules re-entering the condensed phase. The change from the gas phase to the liquid is called condensation. When the rate of condensation becomes equal to the rate of vaporization, neither the amount of the liquid nor the amount of the vapor...
40.6K