Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...

Pharmacogenomics: Identification of New Drug Targets

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reward Circuit Adaptations After Chronic Antipsychotic Treatment Confer Addiction Vulnerability.

bioRxiv : the preprint server for biology·2026

Same author

Piezoelectric materials for tissue engineering and regenerative medicine: From fundamental principles to clinical applications.

Acta biomaterialia·2026

Same author

Retraction of "3D Protein-Based Bilayer Artificial Skin for the Guided Scarless Healing of Third-Degree Burn Wounds in Vivo".

Biomacromolecules·2026

Same author

Quantifying the cost savings of the South Australian Telestroke Service.

Journal of telemedicine and telecare·2026

Same author

ZO-1/Tjp1 and ZO-2/Tjp2 deletion in retinal pigment epithelium causes progressive retinal degeneration.

iScience·2025

Same author

Functionalization of graphene oxide and its applications in tissue engineering and regenerative medicine.

Biomaterials advances·2025

Same journal

Dual-Targeted Radionuclide Therapy with <sup>161</sup>Tb Instigates Anticancer Immunity in "Cold" Murine Prostate Tumor.

Molecular pharmaceutics·2026

Same journal

Development of [<sup>111</sup>In]In-CHX-A″-DTPA-αCD68 for ImmunoSPECT to Image Murine Macrophages.

Molecular pharmaceutics·2026

Same journal

Mechanistic Insight into Self-Gelation Involved in Prescription Design for Optimization of Tablet Performance.

Molecular pharmaceutics·2026

Same journal

[<sup>68</sup>Ga]Ga-DOTA-DP-UBI 29-41: A Novel <sup>68</sup>Ga-Labeled Ubiquicidin 29-41 Derivative Containing d-Proline for Bacterial Infection PET Imaging.

Molecular pharmaceutics·2026

Same journal

Comparative Investigation of the Impact of Sodium Citrate Buffers on Lipid Nanoparticles of circRNA or Linear mRNA.

Molecular pharmaceutics·2026

Same journal

Preclinical Evaluation of <sup>177</sup>Lu-Labeled Anti-CLDN18.2 VHH-Fc for Radioimmunotherapy in Gastric Cancer.

Molecular pharmaceutics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 1, 2026

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

Nanotechnology-based gene-eluting stents.

Debbie Goh¹, Aaron Tan, Yasmin Farhatnia

¹Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, University College London, London NW3 2QG, United Kingdom.

Molecular Pharmaceutics

|February 12, 2013

Summary

This summary is machine-generated.

Gene-eluting stents (GES) offer a novel solution to cardiovascular disease, addressing limitations of bare-metal stents (BMS) and drug-eluting stents (DES). Utilizing nanotechnology, GES promote re-endothelialization to prevent restenosis and stent thrombosis.

More Related Videos

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Published on: September 18, 2015

Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents

Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents

Published on: October 26, 2016

Related Experiment Videos

Last Updated: May 1, 2026

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Published on: September 18, 2015

Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents

Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents

Published on: October 26, 2016

Area of Science:

Cardiology
Biomaterials Science
Nanotechnology
Regenerative Medicine

Background:

Cardiovascular disease remains a leading global cause of mortality.
Percutaneous coronary intervention (PCI) with coronary stenting has transformed cardiology.
Current stents, bare-metal stents (BMS) and drug-eluting stents (DES), have limitations including restenosis and late stent thrombosis.

Purpose of the Study:

To review gene-eluting stents (GES) as a novel alternative to BMS and DES.
To explore the potential of nanotechnology in cardiovascular applications.
To discuss the implications of GES in regenerative medicine.

Main Methods:

Review of existing literature on coronary stenting.
Analysis of the mechanisms of action for BMS, DES, and GES.
Exploration of nanotechnology applications in gene delivery for cardiovascular devices.

Main Results:

Gene-eluting stents (GES) leverage nanotechnology for localized gene delivery.
GES aim to accelerate re-endothelialization, mitigating restenosis and late stent thrombosis.
This approach holds promise for improved outcomes compared to BMS and DES.

Conclusions:

Gene-eluting stents represent a significant advancement in cardiovascular device technology.
Nanotechnology-enabled gene delivery offers a promising strategy for enhancing stent performance.
GES have the potential to reduce cardiovascular mortality and morbidity through regenerative medicine principles.