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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Coronary calcium scanning independently detects coronary artery disease in asymptomatic firefighters: a prospective
Lawrence J Santora1, Priya Pillutla, Teresa Norris
1Orange County Heart Institute and Research Center, 1140 West La Veta, Ste 640, Orange, CA 92668, USA. lsantora@cox.net
Insights
Firefighters show a high prevalence of coronary calcium, a marker of atherosclerosis, exceeding typical risk factor predictions. This finding highlights the need for advanced cardiac screening in this occupational group.
Area of Science:
- Cardiovascular Imaging
- Occupational Health
- Preventive Cardiology
Background:
- Sudden cardiac death is the leading cause of mortality among US firefighters.
- Fire departments utilize physical exams and exercise stress tests for coronary heart disease (CHD) risk assessment.
Purpose of the Study:
- To evaluate if coronary calcium scoring via electron beam computed tomography (EBCT) improves risk stratification in asymptomatic firefighters beyond traditional risk factors.
- To assess the incremental value of EBCT-derived coronary calcium in identifying cardiac risk in firefighters.
Main Methods:
- 399 asymptomatic firefighters underwent EBCT for coronary calcium assessment.
- Agatston scores were calculated and compared to national age- and sex-matched databases to determine calcium percentiles.
- Framingham risk factor data were collected via questionnaire.
Main Results:
- Coronary calcium was detected in men over 34 years old.
- 53% of firefighters had detectable coronary calcium (Agatston score > 0), with 87% showing scores higher than the national average (P < 0.01).
- 57% of firefighters had Agatston scores above the 75th percentile; traditional risk factors did not correlate with calcium presence.
Conclusions:
- Firefighters exhibit a substantial burden of calcified coronary atherosclerosis.
- The prevalence of coronary calcium in firefighters is higher than predicted by age and traditional risk factors.
- Coronary calcium assessment may offer valuable risk stratification for firefighters.
Background:
Sudden cardiac death is the leading cause of death among firefighters in the United States. Fire departments commonly maintain physical examination protocols, often with exercise stress testing, to detect risk of coronary heart disease.
Objective:
We sought to determine whether coronary calcium detected by electron beam computed tomography (EBCT) adds incremental risk stratification beyond the traditional risk factors in asymptomatic community-based firefighters.
Methods:
Three hundred ninety nine asymptomatic firefighters underwent a coronary calcium scan on a GE/Imatron C-150 Ultrafast EBCT scanner, using standardized imaging protocols. Framingham risk factor data were obtained on each patient by using a questionnaire. Agatston scores were derived and compared with national database of Agatston scores for asymptomatic populations on the basis of age and sex, allowing determination of a calcium percentile for each score.
Results:
Coronary calcium was found only in men >34 years of age. Of the 53% who had positive scans (Agatston score > 0), 87% had higher than average Agatston scores compared with a national database (P < 0.01). Agatston score above the 75th percentile was found in 57% of firefighters. No correlation was observed between traditional risk factors and those with and without coronary calcium.
Conclusions:
Firefighters have a high burden of calcified coronary atherosclerosis, greater than anticipated on the basis of age and coronary risk factors.
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