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Neonatal Endogenous Endophthalmitis Complicated by Spontaneous Globe Rupture: A Case Report
Mary Robinson1, Apurwa Naik2, Cigdem Ozturk3
1Department of Pediatrics, Nemours Children's Health, Orlando, FL, USA.
The American Journal of Case Reports
|August 13, 2026
Summary
Neonatal sepsis can lead to rare endophthalmitis (inner eye infection) and globe rupture. Early recognition of ocular signs and prompt ophthalmologic evaluation are crucial for management in neonates.
Area of Science:
- Ophthalmology
- Neonatology
- Infectious Diseases
Background:
- Presents a rare case of endophthalmitis with spontaneous globe rupture in a neonate.
- Highlights the challenges in recognizing early signs of ocular complications in premature infants.
Purpose of the Study:
- Raise awareness of rare but severe complications of neonatal sepsis.
- Emphasize key clinical management strategies for neonatal endophthalmitis and globe rupture.
Main Methods:
- Case report of a neonate with sepsis and multisystem organ failure.
- Clinical examination, B-scan ultrasonography, and infectious studies (including cytomegalovirus testing).
Main Results:
- Observed eye drainage initially treated as conjunctivitis.
- B-scan revealed suspected bilateral intraocular infection and right globe rupture.
- Cytomegalovirus testing was positive; blood and ocular cultures were negative.
Conclusions:
- Endogenous endophthalmitis signs can be subtle in premature infants.
- Prompt ophthalmologic evaluation is essential for neonates with systemic infection and new ocular signs.
- Further reviews of rare complications like spontaneous globe rupture are needed for improved neonatal care.
