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Cognitive functioning in psychiatric disorders following deep brain stimulation.

Isidoor O Bergfeld1, Mariska Mantione, Mechteld L C Hoogendoorn

  • 1Department of Psychiatry, Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands. i.o.bergfeld@amc.nl

Brain Stimulation
|February 12, 2013
PubMed
Summary

Deep brain stimulation (DBS) for psychiatric disorders like Tourette syndrome (TS), obsessive-compulsive disorder (OCD), and major depressive disorder (MDD) does not appear to cause cognitive decline. Some studies even suggest cognitive improvements may occur with DBS treatment.

Keywords:
Deep brain stimulationNeuropsychological testsPsychiatric diagnosisTreatment outcome

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neurosurgery

Background:

  • Deep brain stimulation (DBS) is an established treatment for Parkinson's disease.
  • DBS is increasingly explored for psychiatric conditions including Tourette syndrome (TS), obsessive-compulsive disorder (OCD), and major depressive disorder (MDD).
  • While cognitive decline is noted in Parkinson's patients post-DBS, its cognitive effects in psychiatric populations remain unexamined.

Purpose of the Study:

  • To systematically review the existing literature on cognitive functioning in psychiatric patients undergoing DBS.
  • To assess the impact of DBS on cognition in individuals with TS, OCD, MDD, and other psychiatric disorders.

Main Methods:

  • A comprehensive literature search was conducted across PubMed, EMBASE, and Web of Science databases up to September 2012.
  • 1470 papers were identified, and 26 studies meeting specific inclusion criteria were selected for analysis.
  • These studies focused on the cognitive functioning of psychiatric patients treated with DBS.

Main Results:

  • The review included data from 130 psychiatric patients (37 TS, 56 OCD, 28 MDD, 6 Alzheimer's, 3 other).
  • No studies reported significant cognitive deterioration following DBS in these patients.
  • Conversely, 13 studies indicated improvements in cognitive functioning after DBS treatment.

Conclusions:

  • Preliminary findings suggest DBS does not induce cognitive decline in psychiatric patients.
  • Cognitive enhancement was observed in some cases, though not definitively attributable to DBS.
  • Significant study limitations necessitate cautious interpretation and highlight the need for future research with improved methodologies.