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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
[Mantle cell lymphoma diagnosis]
Mohammed Choukri1, Hafsa Taheri, Rachid Seddik
1Laboratoire central, Hôpital Al Farabi-Oujda, Rabat, Maroc. choukrimohammed@hotmail.com
Annales De Biologie Clinique
|February 12, 2013
Summary
Mantle cell lymphoma (MCL) is a distinct non-Hodgkin's lymphoma subtype. Diagnosis relies on morphology, immunophenotype, and cytogenetics for effective treatment strategies.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Mantle cell lymphoma (MCL) is a distinct subtype of non-Hodgkin's lymphoma, comprising 3-10% of cases.
- Recent classifications emphasize morphologic, immunophenotypic, and cytogenetic criteria for MCL identification.
- MCL serves as a model for understanding and treating hematologic malignancies.
Observation:
- The study details two MCL cases from Rabat Ibn Sina hospital.
- Morphological analysis reveals diffuse or nodular lymph infiltration in the mantle zone.
- Osteo-medullary biopsies show interstitial infiltration with centrocytelike lymphocytes.
Findings:
- Flow cytometry identified a characteristic MCL immunophenotype: positive for surface Ig, CD19, CD20, CD22, CD79b, CD5, and cyclin D1.
- Key negative markers include CD10, CD23, and CD25.
- Morphologic features include cleaved, angular nuclei, dispersed chromatin, inconspicuous nucleoli, and scanty cytoplasm.
Implications:
- Accurate diagnosis and prognosis of MCL depend on integrated analysis.
- Diagnostic methods encompass nodular, medullary, and blood morphology.
- Immunophenotypic, cytogenetic, and molecular studies are crucial for evaluating neoplastic cells.
